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package Ace::Sequence::Transcript; |
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use strict; |
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use Ace; |
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use Ace::Sequence::Feature; |
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use vars '$AUTOLOAD'; |
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use overload |
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1
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'""' => 'asString', |
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; |
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*sub_SeqFeature = *merged_segments = *segments = \&exons; |
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15
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16
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sub AUTOLOAD { |
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24
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854
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my($pack,$func_name) = $AUTOLOAD=~/(.+)::([^:]+)$/; |
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24
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224
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my $self = shift; |
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24
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349
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$self->{base}->$func_name(@_); |
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} |
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21
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22
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0
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sub DESTROY { } |
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24
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sub new { |
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11
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0
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117
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my $class = shift; |
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11
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88
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my $args = shift; |
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11
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169
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bless $args,$class; |
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11
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130
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return $args; |
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39
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40
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} |
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41
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42
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0
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sub smapped { 1; } |
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43
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44
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sub asString { |
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45
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2
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2
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0
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96
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shift->{base}->info; |
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46
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} |
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47
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48
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sub type { |
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49
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0
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0
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0
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0
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return 'Transcript'; |
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50
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} |
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51
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52
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sub relative { |
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53
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6
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6
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1
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153
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my $self = shift; |
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54
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6
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57
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my $d = $self->{relative}; |
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55
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6
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100
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65
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$self->{relative} = shift if @_; |
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56
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6
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69
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$d; |
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57
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} |
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58
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59
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sub introns { |
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60
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0
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1
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my $self = shift; |
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61
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0
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0
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0
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return $self->{intron} ? @{$self->{intron}} : () unless $self->relative; |
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0
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0
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0
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62
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63
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0
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0
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my $base = $self->{base}; |
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64
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0
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0
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my @e = map {Ace::Sequence->new(-refseq=>$base,-seq=>$_)} @{$self->{intron}}; |
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0
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0
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0
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0
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65
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0
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return $self->strand < 0 ? reverse @e : @e; |
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66
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} |
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67
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68
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sub exons { |
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69
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4
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4
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1
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79
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my $self = shift; |
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70
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4
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50
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43
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return $self->{exon} ? @{$self->{exon}} : () unless $self->relative; |
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2
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100
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37
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71
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72
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2
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20
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my $base = $self->{base}; |
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73
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2
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18
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my @e = map {Ace::Sequence->new(-refseq=>$base,-seq=>$_)} @{$self->{exon}}; |
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16
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252
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2
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22
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74
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2
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100
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34
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return $self->strand < 0 ? reverse @e : @e; |
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75
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} |
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76
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77
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sub cds { |
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78
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0
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0
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1
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my $self = shift; |
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79
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0
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0
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return $self->{cds} ? @{$self->{cds}} : () unless $self->relative; |
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0
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0
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80
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81
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0
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my $base = $self->{base}; |
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82
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0
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my @e = map {Ace::Sequence->new(-refseq=>$base,-seq=>$_)} @{$self->{cds}}; |
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0
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0
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83
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0
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0
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return $self->strand < 0 ? reverse @e : @e; |
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84
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} |
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85
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86
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1; |
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87
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88
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__END__ |
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89
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90
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=head1 NAME |
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91
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92
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Ace::Sequence::Transcript - Simple "Gene" Object |
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93
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94
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=head1 SYNOPSIS |
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95
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96
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# open database connection and get an Ace::Object sequence |
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97
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use Ace::Sequence; |
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98
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99
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# get a megabase from the middle of chromosome I |
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100
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$seq = Ace::Sequence->new(-name => 'CHROMOSOME_I, |
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101
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-db => $db, |
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102
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-offset => 3_000_000, |
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103
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-length => 1_000_000); |
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104
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105
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# get all the transcripts |
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106
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@genes = $seq->transcripts; |
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107
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108
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# get the exons from the first one |
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109
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@exons = $genes[0]->exons; |
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110
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111
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# get the introns |
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112
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@introns = $genes[0]->introns |
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113
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114
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# get the CDSs (NOT IMPLEMENTED YET!) |
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115
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@cds = $genes[0]->cds; |
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116
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117
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=head1 DESCRIPTION |
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118
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119
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Ace::Sequence::Gene is a subclass of Ace::Sequence::Feature. It |
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120
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inherits all the methods of Ace::Sequence::Feature, but adds the |
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121
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ability to retrieve the annotated introns and exons of the gene. |
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122
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123
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=head1 OBJECT CREATION |
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124
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125
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You will not ordinarily create an I<Ace::Sequence::Gene> object |
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126
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directly. Instead, objects will be created in response to a |
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127
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transcripts() call to an I<Ace::Sequence> object. |
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128
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129
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=head1 OBJECT METHODS |
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130
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131
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Most methods are inherited from I<Ace::Sequence::Feature>. The |
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132
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following methods are also supported: |
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133
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134
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=over 4 |
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135
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136
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=item exons() |
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137
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138
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@exons = $gene->exons; |
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139
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140
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Return a list of Ace::Sequence::Feature objects corresponding to |
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141
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annotated exons. |
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142
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143
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=item introns() |
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144
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145
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@introns = $gene->introns; |
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146
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147
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Return a list of Ace::Sequence::Feature objects corresponding to |
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148
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annotated introns. |
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149
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150
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=item cds() |
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151
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152
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@cds = $gene->cds; |
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153
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154
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Return a list of Ace::Sequence::Feature objects corresponding to |
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155
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coding sequence. THIS IS NOT YET IMPLEMENTED. |
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156
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157
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=item relative() |
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158
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159
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$relative = $gene->relative; |
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160
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$gene->relative(1); |
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161
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162
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This turns on and off relative coordinates. By default, the exons and |
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163
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intron features will be returned in the coordinate system used by the |
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164
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gene. If relative() is set to a true value, then coordinates will be |
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165
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expressed as relative to the start of the gene. The first exon will |
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166
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(usually) be 1. |
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167
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168
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=head1 SEE ALSO |
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169
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170
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L<Ace>, L<Ace::Object>, L<Ace::Sequence>,L<Ace::Sequence::Homol>, |
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171
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L<Ace::Sequence::Feature>, L<Ace::Sequence::FeatureList>, L<GFF> |
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172
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173
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=head1 AUTHOR |
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174
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175
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Lincoln Stein <lstein@cshl.org> with extensive help from Jean |
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176
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Thierry-Mieg <mieg@kaa.crbm.cnrs-mop.fr> |
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177
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178
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Copyright (c) 1999, Lincoln D. Stein |
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179
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180
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This library is free software; you can redistribute it and/or modify |
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181
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it under the same terms as Perl itself. See DISCLAIMER.txt for |
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182
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disclaimers of warranty. |
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183
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184
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=cut |
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185
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186
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